An overview of current strategies and future prospects in drug repurposing in tuberculosis

A large number of the population faces mortality as an effect tuberculosis (TB). The line treatment in management TB a jolt with ever-increasing multi-drug resistance (DR) cases. Further, drugs engaged are associated different toxicities, such renal and hepatic toxicity. Different combinations sought for effective anti-tuberculosis (anti-TB) effects decrease In this regard, drug repurposing has been very promising improving efficacy by enhancement bioavailability widening safety margin. success lies specified binding inhibition particular target molecule. have repurposed various ailments like cancer, Alzheimer’s disease, acquired immunodeficiency syndrome (AIDS), hair loss, etc. Repurposing anti-TB holds great potential too. use whole-cell screening assays availability chemical compounds testing against Mycobacterium poses challenge development. target-based discovery sites emerged form phenotypic ethionamide R (EthR) malate synthase inhibitors similar to pharmaceuticals. review, authors thoroughly described techniques on basis pharmacogenomics metabolism, pathogen-targeted therapy, host-directed bioinformatics approaches identification drugs. significance elaborated databases revealed. role genomics network-based methods also discussed article.